With max Point Strike Synapse's crit chance can be increased up to 125%, ensuring critical hits and good chance at mega-crits, though a Rank 3 Point Strike will be sufficient to increase its crit chance to 100% if low on mod energy.
As mentioned above, using the Synapse in conjunction with Volt's Electric Shield worsens the Synapse's imperfect accuracy. When using Heavy Caliber, the accuracy is somewhat low at even medium range.
As of Update 11, the Synapse can no longer do constant red crits when used in conjunction with Volt's Electric Shield.
Its high rate of fire, high status effect chance, and innate elemental nature allows it to be used very effectively with elemental modifications. By applying an elemental effect other than electricity you can reduce armor, reduce shields, or apply confusion with ease.
Crafting the Synapse used to require 11 Mutagen Masses and 3 Forma before being announced as a mistake, reducing it down to 5 and 2 respectively.
Synapse is the only weapon to require two Formas to be built.
The tendrils at the front end of the Synapse move, retracting and enclosing the muzzle upon holstering the rifle. This suggests the weapon is a living organism.
A Synapse is a nervous system structure that acts as a 'gate' between neurons, allowing electrical signals to be passed between nerve cells. Synapses help form the electrical pathways of the nervous system.
This weapon seems to be based on the Electric Crawler as it has similar lighting attacks.
The Synapse resembles the Shock Roach weapon from the game Half-Life: Opposing Force.