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Oxium is a rare lighter than air alloy of Orokin origin, used in certain Corpus Robotics.
Oxium is an uncommon component. Dropped by the uncommonly encountered Oxium Osprey with a guaranteed drop rate, it can be found in quantities of 7-12 and will only drop if the Osprey is killed before it destroys itself by charging against the player, an ally, or a wall.
Ivara can use Prowl on the Ospreys, potentially doubling the amount of Oxium dropped by a single unit.
As it's dropped by a specific enemy and is not a planet-specific drop, it cannot be obtained by using Extractors.
Sometimes Oxium can get stuck in the ceiling in narrow hallways/locations with a low ceiling, Loot Radar mods (Animal Instinct & Thief's Wit) can help locating those otherwise invisible resource drops.
Oxium can also be acquired from Grineer/Corpus/Orokin storage containers, albeit with a very low chance. Therefore, one should not rely on this source due to it being infrequent.
Nidus can use Larva to catch Oxium Ospreys, leaving them open for potshots before they have a chance to destroy themselves while also potentially granting him Mutation stacks as well. Doing it this way however, it is ill-advised to melee the Oxium Ospreys as they can still detonate if they aren't destroyed quickly enough.
Each player obtains a different amount of Oxium from the same pickup, implying that the amount of Oxium contained in a pickup is not pre-determined.
Recommended manner of dealing with Oxium Ospreys before they self-destruct without dropping the desired resource is incapacitating them before they are able to see the enemy and attack. Otherwise focusing on diverting their attention from fighting (Terrify, Radial Blind, Rest & Rage, and similar abilities) is a good way of approaching the situation.
Sorties seem to have somewhat higher spawn rates for the Ospreys.
By purchasing this item you can directly exchange 30 Platinum 30 for 300 Oxium.