Operation: Plague Star is a reoccurring event introduced Update 22.3 (2017-11-15), where players are tasked to destroy an Infested meteorite that crashes in the Plains of Eidolon, with its passengers threatening to overwhelm both Ostron and Grineer alike. On the PC build, the event originally began on November 15, 2017 and ran until November 27, 2017.

Unlike most events in WARFRAME, Operation: Plague Star is a reoccurring event, with the Infested "boil" regrowing every several months and the Tenno are called on to cull it once more.

Plague Star Appearances

Event Start Event End Total Duration
First Appearance November 15, 2017 (PC)
December 1, 2017 (Consoles) [1]
November 27, 2017 (PC)
December 18, 2017 (Consoles)
1 week, 5 days (PC)
2 weeks, 3 days (Consoles)
First Reappearance April 5, 2018 (PC) [2]
May 10, 2018 (Consoles) [3]
April 17, 2018 (PC)
May 22, 2018 (Consoles)
1 week, 5 days
Second Reappearance September 19, 2018 (PC) [4]
November 2, 2018 (Consoles) [5]
September 30, 2018 (PC)
November 13, 2018 (Consoles)
1 week, 4 days
Third Reappearance June 14, 2019 (All Platforms) [6]* June 26, 2019 (All Platforms)* 1 week, 5 days
Fourth Reappearance January 17, 2020 (All Platforms) [7] January 27, 2020 (All Platforms) 1 week, 3 days
Fifth Reappearance September 8, 2021 (All Platforms) [8] September 30, 2021 (All Platforms) 3 weeks, 1 day

*This was the first time this event happened for Nintendo Switch players. All previous instances of this event on consoles were limited to the PS4 and Xbox One builds.

Event Synopsis

Rally your Squad and defend the Plains of Eidolon!

A mysterious meteorite has crashed just outside of Cetus revealing a horrific boil. The boil is growing and the Ostrons have sighted Infested life forms emerging from it. We need to act now before they make their way to Cetus.

Konzu has received reports that Vay Hek possesses a toxin that can destroy the boil. But Vay Hek won’t help; he sees this infested boil as a means to rid the Plains of Cetus of the Ostrons.

We need to obtain a batch of the toxin and destroy the boil before it becomes unstoppable. Visit Konzu in Cetus to learn his plan for retrieving the toxin from Vay Hek.

What You Need To Do

A Grineer Thrax Toxin storage container in a cave. Note that they are non-interactible outside of the Plague Star bounty.

  • For the duration of the event Konzu has a specific Plague Star Bounty where players are tasked with stealing the Toxin from the Grineer and using it on the boil. The Bounty is divided into four phases;
    • First, players must raid the Grineer's Thrax Toxin storage, which is located in one of the various Caves that dot the plains. The Toxin storage unit has a rounded pyramid shape dotted with yellow lights, with orange fluid visible inside of it and a container rising and sinking on top of it. It is generally located at the far end of the cave.
    • After acquiring the Thrax Toxin, players must head to a Toxin mixer, which will spawn in an Armored Vault in a given Grineer outpost. Once the Toxin is put in the mixer, players must then defend the mixer for 3 minutes from Grineer troops.
      • During the mixing phase, players may opt to add either Eidolon Phylaxes and/or Infested Catalysts, increasing the Standing reward from the bounty in exchange for increased difficulty later on. Up to 4 of each can be mixed with the Toxin.
      • The blueprint for Eidolon Phylaxis is purchasable from the Operational Supply Syndicate, which is available during the event, while the blueprint for the Infested Catalyst is available from Clan Bio Lab Research.
    • Once the Toxin is mixed, players are instructed to head to a downed Grineer Drone which will deliver the Toxin to the boil. As with Drone Hijack missions, players must defend the drone from Grineer and Infested attackers as it travels to the boil.
    • When the Drone reaches the boil, the boil responds by spawning Infested to defend itself. Here players must thin out the Infested horde while the Toxin poisons the boil, with a percentage gauge denoting their progress. The decisions made during the Mixing phase affect the difficulty of this phase;
      • For every Eidolon Phylaxis mixed with the Toxin, both the density of the Infested and their level range increases, up to level 30 if 4 Phylaxes were added.
      • For every Infested Catalyst mixed with the Toxin, a Hemocyte will spawn at specific points, pausing the percentage gauge until players defeat it. The Hemocyte can spawn up to 4 times if 4 Catalysts were added, with its level(s) affected by the presence or absence of Eidolon Phylaxis. Check its page for more details.
    • Once the gauge reaches 100%, the Bounty is completed, awarding a variable amount of Standing based on how many Eidolon Phylaxes and/or Infested Catalysts were mixed with the Toxin. Players are free to remain on the Plains, return to Cetus or visit a bounty tent to undertake the mission again.

What You Need To Know

  • Throughout the duration of the event, the Infestation will spawn on the Plains of Eidolon regardless if the player is doing the Bounty or not, and will attack nearby Tenno, Grineer, and even the Eidolons during the night.
  • The boil deals 200 Toxin DamageDmgToxinSmall64.png Toxin damage per second to any Tenno standing on or even flying close to it, so players are advised to stay away from it as much as possible.
    • The damage will not affect enemies in any way, allowing them to walk on the boil without issue.
    • In the event that a player does get knocked down from the boil's damage, it is recommended to use a Revive instead of someone risking a rescue, as the damage may bring the rescuer(s) down as well.

Event Rewards

Operational Supply Standing

Main article: Operational Supply
  • The base standing reward is 1,000. An extra 250 is rewarded per Eidolon Phylaxis and 250 per Infested Catalyst mixed into the toxin, for an additional 2,000 standing points. The third stage has a bonus objective that grants 50 standing. Thus a maximum possible standing reward of 3,050.
  • Unlike most events, players can select their Operation Rewards through the Operational Supply Syndicate, which is only accessible from Nakak during Operation: Plague Star. The Syndicate has its own rank system, and players can spend the Standing gained from the Plague Star bounty on the following rewards;
Rank & Title Sacrifice Benefits Standing
(Minimum to Maximum)
FactionSigilOperationalSupplyLevel3 b.png
3 - Champion
10 Nistlepod64.png Nistlepod Credits64.png 20,000
ReputationBlackx64.png 3,000
Access to Rank 3 wares
One free Rank 3 item from Operational Supply
0 to 494,000
FactionSigilOperationalSupplyLevel2 b.png
2 - Defender
10 Iradite64.png Iradite Credits64.png 10,000
ReputationBlackx64.png 2,000
Access to Rank 2 wares
One free Rank 2 item from Operational Supply
0 to 3,000
FactionSigilOperationalSupplyLevel1 b.png
1 - Collaborator
10 Grokdrul64.png Grokdrul
Credits64.png 5,000
ReputationBlackx64.png 1,000
Access to Rank 1 wares
One free Rank 1 item from Operational Supply
0 to 2,000
0 - Neutral
- - Access to base wares 0 to 1,000

Operational Supply Offerings

Rank 0: Neutral
Plague Star Emblem
Rank 0: Neutral
Cetus Wisp
Rank 0: Neutral
Radian Sentirum
Rank 0: Neutral
Heart Nyth
Rank 0: Neutral
Murkray Liver
Rank 0: Neutral
Norg Brain
Rank 0: Neutral
Cuthol Tendrils
Rank 0: Neutral
Rank 0: Neutral
Rank 0: Neutral
Rank 1: Collaborator
Snipetron Blueprint
Rank 1: Collaborator
Ether Daggers Blueprint
Rank 2: Defender
Exodia Contagion
Rank 2: Defender
Exodia Epidemic
Rank 3: Champion
Ghoulsaw Blueprint
Rank 3: Champion
Ghoulsaw Grip Blueprint
Rank 3: Champion
Butcher's Revelry
Rank 3: Champion
Plague Akwin Blueprint
Rank 3: Champion
Plague Keewar Blueprint
Rank 3: Champion
Plague Bokwin Blueprint

Hemocyte Drops

  • Additionally, the Hemocyte will also drop a Hemocyte Cystolith, which is a required component for constructing a Clan trophy.
  • If a player wishes to acquire all the exclusive rewards (excluding gear items) the player will need a total, from 0, 133,500 (127,500 from rank 3) standing. This excludes items such as Fosfor and Ether Daggers as those are found elsewhere but does include the Snipetron. Depending on the use of the mixable gear will vastly shorten the required runs. From rank 3 using 0/4 0/4 will require 104.5 runs, [0/4]/4 [4/0]/4 will require 52.25 runs, and 4/4 4/4 will require only 34.83~ runs.

Bounty Rewards

Endo64.png 300 Endo 24.72%
FusionCorePackSilversingle.png Augur Message 24.72%
Kuva64.png 100 Kuva 23.6%
FocusLens1Rank sq.png Naramon Lens 14.61%
Axi A14 Relic 1.12%
Axi I2 Relic 1.12%
Axi M2 Relic 1.12%
Lith N7 Relic 1.12%
Lith T7 Relic 1.12%
Meso B5 Relic 1.12%
Meso B6 Relic 1.12%
Meso S10 Relic 1.12%
Neo N16 Relic 1.12%
Neo N17 Relic 1.12%
Neo T5 Relic 1.12%

Module:DropTables/data last updated: Mon, 20 Sep 2021 23:37:05 +0000 (UTC) by User:Cephalon Scientia

Chassis.png Revenant Chassis Blueprint 13.95%
FusionCorePackSilversingle.png Vigilante Pursuit 13.95%
CetusWisp64.png Cetus Wisp 13.95%
Endo64.png 300 Endo 12.79%
FusionCorePackSilversingle.png Augur Message 12.79%
Kuva64.png 100 Kuva 12.21%
FocusLens1Rank sq.png Naramon Lens 7.56%
Axi A14 Relic 0.58%
Axi A14 Relic 0.58%
Axi I2 Relic 0.58%
Axi I2 Relic 0.58%
Axi M2 Relic 0.58%
Axi M2 Relic 0.58%
Lith N7 Relic 0.58%
Lith N7 Relic 0.58%
Lith T7 Relic 0.58%
Lith T7 Relic 0.58%
Meso B5 Relic 0.58%
Meso B5 Relic 0.58%
Meso B6 Relic 0.58%
Meso B6 Relic 0.58%
Meso S10 Relic 0.58%
Meso S10 Relic 0.58%
Neo N16 Relic 0.58%
Neo N16 Relic 0.58%
Neo N17 Relic 0.58%
Neo N17 Relic 0.58%
Neo T5 Relic 0.58%
Neo T5 Relic 0.58%

Module:DropTables/data last updated: Mon, 20 Sep 2021 23:37:05 +0000 (UTC) by User:Cephalon Scientia


  • This event was first teased as a meteor crossing the sky over the Plains of Eidolon after Update 22.2 (2017-11-01), and officially announced during Devstream 100 on November 3, 2017, with the meteoroid crashing into the Plains at 3pm EST in the middle of the Devstream.
    • The event was supposed to start shortly after it crashed into the Plains, but various issues led to the event being delayed until November 15, 2017.
  • The meteoroid was instantly visible in the Plains after the official announcement. Players that were on the Plains during the event could see it after leaving to Cetus and re-entering.
  • As of Update 30.7 (2021-09-08), this event has the most opposing factions present in one mission: the Tenno, the Grineer, the Infested, and, at night time, the Sentients and Vasca Kavats.
    • The Steel Path will also spawn an Acolyte every few minutes, bringing the total number of factions to six.
  • During the last phase of the bounty, the Lotus may tell the player that the toxin has caused the boil to undergo peristalsis, which is a one-way muscular contraction/relaxation wave commonly associated with the digestive tract.


Warframe - OPERATION PLAGUE STAR - Complete Guide
Operation Plague Star, As Fast As Possible

Patch History

Hotfix 30.7.3 (2021-09-10)

  • Fixed Infested enemy spawns in Plague Star fleeing to Cetus when attempting to play the Bounty back to back.

Hotfix 30.7.2 (2021-09-09)

  • Fixed an extremely precise Loki Switch Teleport on the Plague Star Escort Drone resulting in ability to skip most of the third Bounty stage wherein players were sending the Drone off-navigation into a Sniper Tower as an exploit.

Update 30.7 (2021-09-08)


Plague Star has returned and runs from Sept 8 at 2pm ET to Sept 30 at 2pm ET, Tenno!

- NEW: Ghoulsaw & Butcher’s Revelry Stance!

  • Hemocyte is now immune to looting abilities that often didn’t fully work due to how quickly the body despawns (Hydroid's Tentacle Swarm with Pilfering Swarm, Nekros' Desecrate etc).
    • With the re-run of Plague Star, we are adding Nidus Prime’s Relics as in-world drops from the Hemocyte. This change was brought forth with this in mind, and the acquisition rate of this new Prime that could be influenced with loot abilities which is not a precedent we wish to set. With up to 4 Hemocytes that can spawn in the final stage it felt especially important to make this change.
  • Fixed ability to ride on top of the Plague Star Infested boil with K-Drives (and other similar vehicles) which resulted in taking no damage.
  • We have made the following fixes for Plague Star:
    • We fixed an issue where the Plague Star Bounty drone would automatically start without being hacked once the player was in its proximity.
    • Fixed an issue where Nakak was talking to herself silently after you looked at the Offerings page

Hotfix 30.6.1 (2021-08-10)

  • While not currently applicable, we felt it important to note that we’ve made improvements towards Drone pathing in Plague Star that resulted in the Drone becoming stuck, or stopping short of the Infested Boil. While this logic does carry over to the normal Drone escort mission in the Plains of Eidolon, there are some distinct differences due to the specific path it takes in each scenario.

Update 25.7 (2019-08-29)

  • Better optimized pathing for the Plague Star Drone for next Operation re-run.

Hotfix 25.1.3 (2019-06-14)

  • Reintroduced.
  • More back-end fixes for Plague Star.

Hotfix 23.8.2 (2018-09-19)

  • Reintroduced.

Update 22.20 (2018-05-17)

  • Fixed Dargyns being able to spawn in cave systems during Plague Star.

Update 22.18 (2018-04-20)

  • Fixed Host migrating while fighting the Hemocyte causing bonus Affinity to be lost for using Infested Catalysts and Eidolon Phylaxis.

Hotfix 22.17.3 (2018-04-11)

  • Improved balance between Vomvalyst and Infested enemy spawns during the Plague Star occurrence at night.
  • Lephantis and Hemocyte healthbar will now move to the appropriate heads when they are being aimed at.

Hotfix 22.17.2 (2018-04-10)

  • Fixed some behavior issues for the Hemocyte that was causing it to frequently turn on the spot.

Hotfix 22.17.1 (2018-04-05)

  • Reintroduced.
  • Fixed Ember’s Fireblast unintentionally melting Lephantis/Hemocyte heads like a popsicle in July when cast directly on top of them.

Update 22.4 (2017-11-23)

  • Improved the pathing of the hijacked Drone in the Plains. This also fixes issues where the Drone would become stuck on its way to the Boil in Operation: Plague Star.

Hotfix 22.3.5 (2017-11-20)

  • Fixed the Mixer Vault door remaining closed if you already opened the Mixer Vault before getting the Toxin.
  • Fixed leaving the Mixer Defense objective area resulting in breaking the Mixer.
  • Fixed the Plague Star Ancient Infested head of Lephantis snapping to an extreme angle prior to aiming.
  • Fixed an incorrect objective waypoint if the Toxin Dispenser in Stage 1 was activated too early.
  • Fixes towards a script error when Lephantis spawns.

Hotfix 22.3.4 (2017-11-16)

  • Decreased the Operational Supply Standing requirements to their intended values and updated the Sacrifice requirements. New Standing requirements:
    • Rank 1 = 1000 Standing.
    • Rank 2 = 3000 Standing.
    • Rank 3 = 6000 Standing.
  • Refunded the component portion of Operational Supply Sacrifices. New Sacrifice requirements:
    • The 2x Neurodes Sacrifice to Collaborator has been replaced with 10x Grokdrul.
    • The Forma Sacrifice to Defender has been replaced with 10x Iradite.
    • The Mutagen Sample Sacrifice to Champion has been replaced with 10x Nistlebrush.
  • Fixes towards the Plague Star Bounty failing on Stage 2.
  • Fixes towards the hijacked Drone getting stuck while navigating to the boil.
  • Fixed Infested drop pods spawning far away or on top of the boil.
  • Fixed the Infested Catalyst not being Chat linkable for those that own it.

Hotfix 22.3.3 (2017-11-16)

  • Konzu now explains that rewards are at Nakak for the Operation.

Hotfix 22.3.2 (2017-11-15)

  • Removed “Clear Remaining..” stage of the Operation.
  • Increased likelihood of encountering Infested in the Plains.
  • Reduced chance to receive Lens from Operation Bounty.
  • Fixed another common crash during the Operation.
  • Fixed console being invisible for Clients in the Operation.
  • Fixed Infested pods in the Operation not showing VFX when destroyed.
  • Fixed a script error that could occur for clients during the Operation.
  • Fixed Infested Scream FX now showing for Clients.

Update 22.3 (2017-11-15)

  • Introduced.