Once Awake is a main Quest, introducing new players to the faction of the 
Infested, as well as the Spy and Defense mission modes.
Synopsis
Dr. Tengus, a Grineer doctor, has been experimenting with a bio-weapon of some sorts and the player is tasked to investigate. The player discovers that this bio-weapon the Grineer was working on was a strain of the Infestation that survived the events of The Old War. After a failure in a testing lab, the Infested broke out from quarantine and invaded Grineer outposts and ships on Mercury. As the possibility of an Infested outbreak was a threat to the Origin System, the Lotus commands the player to eradicate the Infestation. With the help of a Cascade Bomb infused with Void energy, the player successfully eliminated the source of the Infestation. However, because of the continued research efforts of Dr. Tengus, the System is not immune from future outbreaks.
Walkthrough
Investigate the Bio Weapon: M Prime, Mercury
The Lotus delivers an inbox message that has decrypted Grineer communications that a doctor named Tengus has acquired some sort of bio weapon. The player is tasked to a Grineer Spy Mission on M Prime, Mercury to collect three data units for retrieval from a Grineer Asteroid base.
After the first data unit is recovered, Tengus' assistant expresses anger that the Tenno are there, demanding absolute secrecy in their project and thus ordering the marines to assault the Tenno.
After the second data unit is recovered, panic breaks loose as a new enemy, the Infestation, has broken free from quarantine, fighting both Grineer and Tenno. After the third and final data unit is recovered, the Grineer soldiers blame Dr. Tengus for the outbreak, while the Lotus believes that the Infested were released on purpose.
The mission is considered complete if the player reaches the extraction with at least one data unit extracted.
Infestation Outbreak: Terminus, Mercury
The next mission takes place in Terminus, Mercury, where players are tasked with exterminating all Infested units aboard a Grineer Galleon overrun by the Infestation. Upon completing the mission, the Lotus decrypts a report from Tengus that the Grineer marines that survived the longest against the Infestation were using 
Heat-based weaponry, awarding the 
Molten Impact mod.
Cascade Bomb: Lares, Mercury
The Lotus sends the Tenno to Lares, Mercury, in an attempt to destroy the Infested there by using a Cascade Bomb planted on the asteroid's power core, that will use Void energy to eliminate all organic life while leaving the structure intact. This mission takes the form of a Defense mission where the player has to prevent the Infested from destroying the Power Core for eight waves. Notable differences from the standard Grineer Asteroid defense mission includes the large masses of Infested biomass surrounding the power core and having only two access points to the core instead of three. During the mission, the Lotus makes note that while the Infested appear to be mindless, they seem to know what the Tenno are up to and are trying to stop them.
After the mission is completed, the Lotus will message players to reward them with a 
Heat Sword blueprint, concluding the quest. She will also inform the Tenno that Saya in Cetus wishes to see them, unlocking the Shrine Defense mission.
An additional intercepted message will be sent to players detailing a report by Doctor Tengus' to the Twin Queens, blaming the Tenno for the outbreak at the facility and taking credit for its destruction while claiming the Tenno have obtained Infested spores and will use them against the Grineer.
Media
Patch History
Hotfix 32.3.1 (2023-02-15)
- Fixed significant lighting issues in the ‘Once Awake’ Tutorial Mission.
- Also made some general improvements to the overall lighting as well!
Hotfix 30.5.1 (2021-07-06)
- Fixed no enemies spawning during the final stage of the Once Awake Quest (Defend the Cascade Bomb).
Update 22.20 (2018-05-17)
- Added the ability to replay the Once Awake quest!
Update 15.2 (2014-11-13)
- Introduced.
