Edit Tab

Command the Infestation to mutate and grow ever more destructive.

This is Nidus, the adaptive, the scourge.

Nidus is a deadly plague for which there is no cure. You must control the strange disease.

Release Date: December 22nd, 2016

Epitome of the endlessly evolving Infestation, Nidus bends the vile corruption to his will, mutates his genetic potency to adapt and assimilates his victims with an insatiable parasitic hunger. Nidus and his strain developed in Update 19.5 (2016-12-22).


Nidus' main blueprint is acquired from The Glast Gambit quest, additional main blueprints can be bought from Cephalon Simaris for ReputationBlackx64.png 50,000. Nidus' component blueprints are acquired from Rotation C of Infested Salvage on Oestrus, Eris.
Source Chance Expected Nearly Guaranteed
Chassis Blueprint 14.29% 12 – 13 C Rotations 52 ± 15 C Rotations
Neuroptics Blueprint 14.29%
Systems Blueprint 14.29%
All drop rates data is obtained from DE's official droptables.

Expected refers to total number of attempts a player can expect to need in order to receive at least one of each drop associated with the respective values.
Nearly Guaranteed refers to the total number of attempts a player needs to obtain a 99%, 99.9%, and 99.99% probability to receive at least one of each drop associated with the respective values.

For more detailed definitions and information on how these number were obtained, visit here.

Manufacturing Requirements
Time: 72 hrs
Rush: Platinum64.png 50
Market Price: Platinum64.png 225 Blueprint Price: N/A
Time: 12 hrs
Rush: Platinum64.png 25
Time: 12 hrs
Rush: Platinum64.png 25
Time: 12 hrs
Rush: Platinum64.png 25


Fair, but the Myconians aren't asking for charity. Their ancestral understanding of the Infestation comes from an Old War relic. A relic that I know, will be of extreme interest to you. Return the Triuna, and the relic will be yours. Fair compensation for the risk.

Ergo Glast on Nidus during The Glast Gambit

Little is known about the history of the Nidus Warframe aside from its Orokin era origins. However, the Myconans have apparently used information learned from their time possessing the relic to produce the Triuna, a person with genetic immunity to the Infestation which they fear due to their hybrid nature, allowing them to harvest Infested flesh as part of their livelihood.

Nidus has a mysterious connection with the Helminth being that resides in the Orbiter, being the only Warframe that can purposely be infected by the Helminth Virus; the extent of this relationship is currently unknown.


Nidus with 100 Mutation Stacks

  • As Nidus has no shields, any Hijack objective will drain his health instead in order to move.
  • Nidus can uniquely access the Orbiter's Helminth Infirmary without the Helminth Segment prerequisite. If he sits in the infirmary's chair, he will be injected with the "Helminth Virus", forming an Infested cyst on the left side of his neck after 24 hours and grows to full size after 7 days, while simultaneously "awakening" the Helminth which will begin to communicate to the Tenno. Nidus can also spread this virus to other players he comes into contact with in combat and in a Clan Dojo or Orbiter, causing the cyst to grow on their Warframe, and those Warframes can also further propagate the virus.
    • The injection will only occur once, and will not happen again to additionally built Nidus. However, Nidus can still receive the cyst from another infected player.
  • When entering the Helminth room, Nidus will automatically switch to his fully infested form (as he appears with 10 Mutation Stacks). As he leaves the room, he will revert to his normal appearance.
  • Nidus' appearance changes as he accumulates Mutation Stacks:
    • At 3 stacks, tendrils will protrude from his neck and upper spine, while the carapace around his ribs will open.
    • At 5 and 7 stacks respectively, the carapace around his thighs and arms will open to reveal more infested flesh and tendrils beneath.
    • At 10 stacks, the sides of his head extend outward to form a pair of horns, also exposing many more tendrils.
  • The bonus 150 armor that Nidus gets from leveling is not affected by armor-boosting Mods such as Mod TT 20px.png Steel Fiber; they only calculate off of the original 300 armor and the extra 150 is added at the end.
    • Despite the above, at max level and max ranked full Umbral Mod Set, Mod TT 20px.png Carnis Carapace, and Mod TT 20px.png Armored Agility, Nidus can end up with 1342.5 armor (for an 81.7% damage reduction) and 1740 health for an approximate effective health of 9508, one of the highest of any Warframe.


Nidus infecting another Warframe

  • The word nidus (Latin root: "nest") is defined as the site of origin for disease or bacteria or a place where bacteria multiplies.
  • Nidus is the first Warframe to use Kuva as a Blueprint ingredient.
  • Nidus is the second Warframe after InarosIcon272.png Inaros to have no base shields whatsoever.
  • Nidus is also the first Warframe to use another type of ability resource besides energy, in the form of Mutation stacks.
  • Nidus is the first and only Warframe to innately regenerate Health.
  • Nidus is the first frame to have extra stat bonuses when leveling up.
  • The screech of Nidus' fourth ability was done by Digital Extremes sound designer, Willem Schonken.[1]


Edit Tab

Mutation is endless. The ravening plague-bearer returns in a long-unseen form, seething with a primal strain of the Infestation. Features altered Mod polarities for greater customization.

We cast our shining child adrift on strange seas. For with time, these starless currents black as mourning may work a sea-change. And if, one grisly dawn, the skies should hurl you, herald-like, back to Earth, remind us, foundling, of what we immaculate ones have lost.

What succulent riches disease's kiss may bring.

My festering demigod. My Nidus.

Release Date: September 8th, 2021

Nidus Prime is the Primed variant of NidusIcon272.png Nidus, sporting enhanced Health, Energy, and Armor. He was released alongside the StrunPrime.png Strun Prime and the MagnusPrime.png Magnus Prime.


Lith, Meso, Neo, and Axi refer to Void Relics  |  (V) Denotes Vaulted Void Relics  |  (B) Denotes Baro Ki'Teer Exclusive Void Relic
Nidus Prime's Relic Drops
Chassis Blueprint Systems Blueprint Blueprint Neuroptics Blueprint
VoidRelicIronIcon64.png Lith N7 Rare VoidRelicBronzeIcon64.png Meso B5 Common VoidRelicGoldIcon64.png Axi A14 Uncommon VoidRelicSilverIcon64.png Neo N16 Rare

Manufacturing Requirements
Time: 72 hrs
Rush: Platinum64.png 50
MarketIcon.png Market Price: Platinum64.png 375 Blueprint2.svg Blueprints Price:N/A
Nidus Prime Neuroptics Blueprint
Time: 12 hrs
Rush: Platinum64.png 25
Nidus Prime Chassis Blueprint
Time: 12 hrs
Rush: Platinum64.png 25
Nidus Prime Systems Blueprint
Time: 12 hrs
Rush: Platinum64.png 25


  • Nidus Prime, compared to NidusIcon272.png Nidus:
    • Higher Health (175/525 vs. 150/450)
    • Higher Energy (125/188 vs. 100/150)
    • Higher Armor (350/525 vs. 300/450)
    • Different Polarities (Madurai Pol.svgNaramon Pol.svgVazarin Pol.svg vs. Madurai Pol.svgVazarin Pol.svg)
  • As a Prime Warframe, Nidus Prime possesses a special passive ability where contact with an Orokin Void Death Orb will release an energy pulse that grants 250 Energy to all nearby allies. This effect can only occur once per Death Orb, and can occur even if the Death Orb has been previously destroyed.
  • Nidus Prime's appearance changes as he accumulates Mutation Stacks:
    • At 3 stacks, black tendrils form on the left side of his face, as well as his entire left arm.
    • At 5 stacks, the tendrils extend to cover his chest and back.
    • At 7 stacks, the right side of his fleshy body becomes covered in a black mass, as the golden metallic spikes on his right arm protrude outward, while tendrils form on his lower body.
    • At 10 stacks, the tendrils extend to cover his entire face and thighs.
  • Virulence130xDark.png Virulence, Larva130xDark.png Larva, Ravenous130xDark.png Ravenous' Maggots and its Infested nests have unique models of Orokin design, appearing twisted and overtaken by Nidus' Infestation.



Edit Tab


The Infestation dwelling within NidusIcon272.png Nidus mutates rapidly when used against his foes, fueling his abilities and yielding various symbiotic benefits. Nidus possesses various passive mechanics highlighted in the tabs below:

Mutation gauge at 100 stacks.

Mutation Stacks are a resource unique to Nidus, indicated by the Mutation counter and gauge displayed in the lower-right on the HUD, above the ability icons.

  • The gauge is divided into 5 sections which represent the number of hits dealt to enemies via Nidus' abilities, while the counter at the center of the gauge keeps track of the number of Mutation stacks up to a maximum of 100.
    • When generating Mutation, the sections light up clockwise. Once all 5 sections have lit up, the gauge completes a cycle and the sections become unlit again, while the counter increases by 1 Mutation stack. The following abilities generate 1/5th of a Mutation stack:
      • Each enemy hit with Virulence130xDark.png Virulence.
      • Each enemy hit by Ravenous130xDark.png Ravenous' maggot explosion.
      • Each enemy killed from any source while held by Larva130xDark.png Larva at a 50% chance.
      • Abilities are not required to deal damage to enemies, only ability contact is needed to increase Mutation stacks.
      • When gaining or losing large numbers of stacks, the gauge only changes one at a time, making it difficult to estimate the actual count.
        • This can be bypassed by briefly switching to the Operator, as this will instantly refresh to the current amount of stacks.
    • Mutation stacks are stored until used by the player. Stacks will not disappear in the event of a host migration.
    • Ability-nullifying enemies such as Nullifier Crewman will drain 1 Mutation stack every 2 seconds, ramping up the drain rate the longer Nidus remains in their radius.
    • Each Mutation stack causes the gauge to gradually appear more infested, and upon reaching 100 stacks the counter is hidden and the gauge is overlapped by Virulence's ability icon colored in red and black.
  • The amount of Mutation stacks stored benefits Nidus' abilities:
    • Increases the damage of Virulence and Ravenous' maggot explosion.
    • ParasiticLink130xDark.png Parasitic Link costs 1 stack to activate instead of using energy.
    • Ravenous costs 3 stacks to activate instead of using energy.
  • Nidus' appearance changes as more stacks are collected:
    • With the base skin:
      • At 3 stacks, tendrils will protrude from his neck and upper spine, while the carapace around his ribs will open.
      • At 5 and 7 stacks respectively, the carapace around his thighs and arms will open to reveal more infested flesh and tendrils beneath.
      • At 10 stacks, certain sections of his currently-equipped helmet will open up.
        • With the base helmet, the sides of his head extend outward to form a pair of horns, also exposing many more tendrils.
        • With the Nidus Prion Helmet, the "mouth" and the ligature open up, revealing Void-like energy underneath.
        • With the Nidus Myxini Helmet, the helmet opens up down the middle to reveal a monstrous mouth-like face.
    • With the Nidus Phryke Skin:
      • At 3 stacks, he gains protective armor on his thighs, and his shoulder pads are covered in a cage-like armor with a protruding spike on the top.
      • At 5 stacks, a large curved blade appears on each of the shoulder pad spikes.
      • At 7 stacks, his forearms are lined with a curved blade that extends two large spikes.
      • At 10 stacks, his face becomes covered with a crown-like visor.
    • With NidusPrimeIcon272.png Nidus Prime:
      • At 3 stacks, black tendrils form on the left side of his face, as well as his entire left arm.
      • At 5 stacks, the tendrils extend to cover his chest and back.
      • At 7 stacks, the right side of his fleshy body becomes covered in a black mass as the golden metallic spikes on his right arm protrude outward, while tendrils form on his lower body.
      • At 10 stacks, the tendrils extend to cover his entire face and thighs.
    • When stacks fall below the required triggers, Nidus' appearance will revert to the appropriate stage.

If Nidus suffers fatal damage with at least 15 stacks of Mutation, Nidus will consume the 15 stacks to avoid bleedout while receiving 5 seconds of invulnerability and restoring 50% of his health.

  • A UI banner displaying "Undying" and an invulnerability timer will appear at the top-center of the screen while this passive is activated. The required amount of Mutation stacks will be visibly subtracted from the counter and gauge.
  • If Nidus has fewer than 15 Mutation stacks, all stacks will be consumed without benefit.
  • If Nidus has 15 or more stacks while Mod TT 20px.png Quick Thinking is equipped, Undying will be given a higher priority, triggering before any energy is drained by Quick Thinking.

Main article: Abundant Mutation

Abundant Mutation is a Warframe Augment Mod for NidusIcon272.png Nidus' passive that increases the amount of max stacks that he can carry but adds a cooldown of 30 seconds to his Undying passive.

Rank Additional max stacks Cost
0 +50 6
1 +100 7
2 +150 8
3 +200 9

Unlike most frames, when Nidus ranks up he receives a special set of rank bonuses which are indicated at the top-left of the Warframe Upgrade screen:

  • +20% / +40% / +60% / +80% / +100% / +120% / +140% / +160% / +180% / +200% Health at ranks 1 / 4 / 7 / 10 / 13 / 16 / 19 / 22 / 25 / 28 respectively.
  • +10% / +20% / +30% / +40% / +50% Armor at ranks 2 / 8 / 14 / 20 / 26 respectively.
  • +3% / +6% / +9% / +12% / +15% Ability Strength at ranks 3 / 9 / 15 / 21 / 27 respectively.
  • +10% / +20% / +30% / +40% / +50% Energy capacity at ranks 5 / 11 / 17 / 23 / 29 respectively.
  • 5 / 7 / 9 / 11 / 13 Health regen per second at ranks 6 / 12 / 18 / 24 / 30 respectively.

This results in a total of +200% Health, +50% Armor, +15% Ability Strength, +50% Energy capacity, and 13 Health/s Regeneration at Rank 30.

Note that these bonuses are gained only by leveling up. Gaining Mutation stacks will not increase said bonuses.


View Maximization
Input table not loaded. Javascript not loaded
Result table not loaded. Javascript not loaded

Virulence.png VirulenceIcon.png
Rupture the ground with a damaging fungal growth that steals energy from each enemy it strikes. For every five enemies hit, the Infestation mutates, multiplying its destructive force.
Strength:150 / 160 / 175 / 200 (DmgPunctureSmall64.png Puncture damage)
Range:10 / 11 / 13 / 16 m
Misc:4 m (fungal growth width)
25% (energy refund rate per hit)

Larva.png LarvaIcon.png
Spawn an Infested pod that erupts with tendrils, latches onto nearby enemies and pulls them in. Enemies killed while held have a chance of generating a Mutation stack.
Duration:4 / 5 / 6 / 7 s
Range:8 / 9 / 10 / 12 m (grab radius)
5.33 / 6 / 6.67 / 8 m
(grab radius for subsumed version)
Misc:50 % (Mutation stack chance)
3 s (unaffected targets release delay)
Subsumable to Helminth

ParasiticLink.png ParasiticLinkIcon.png
Parasitic Link
Bind to a target with parasitic link. When cast on an ally, both the host and Nidus have their Ability Strength increased. Linked enemies take some of the damage inflicted on Nidus.

Mutation Stacks Cost: 1

Strength:10% / 15% / 20% / 25% (strength bonus)
20% / 30% / 40% / 50% (damage redirection)
Duration:30 / 35 / 45 / 60 s
Range:24 / 28 / 34 / 40 m (ally link)
10 / 13 / 16 / 20 m (enemy link)

Ravenous.png RavenousIcon.png
Gluttonous maggots swarm nearby enemies, feasting until they burst with Infestation. The maggots benefit from Mutation and each enemy consumed adds to the Mutation stack.

Mutation Stacks Cost: 3

Strength:100 / 110 / 125 / 150 (explosion DmgBlastSmall64.png Blast damage)
10 / 13 / 16 / 20 (health regen per second)
Duration:25 / 30 / 35 / 40 s
Range:4 m (explosion radius)
Misc:8 m (ability diameter)
9 (number of maggots)
1000 (maggot health)
10 (maggot DmgToxinSmall64.png Toxin damage)

Strength Mods


Duration Mods


Range Mods


VirulenceIcon.png VirulenceIcon.png
LarvaIcon.png LarvaIcon.png
ParasiticLinkIcon.png ParasiticLinkIcon.png ParasiticLinkIcon.png
RavenousIcon.png RavenousIcon.png RavenousIcon.png

Edit Tab

Hotfix 30.7.5 (2021-09-16)

  • Fixed Nidus Prime Larva not using custom colors.

Hotfix 30.7.3 (2021-09-10)

  • Fixed equipping most Skins to Nidus Prime resulting in the Mutation effects not working and there will visibly be pieces missing.
  • Fixed the Helminth Infirmary doors not opening for Nidus Prime for players who do not own the Helminth Segment.

Hotfix 30.7.1 (2021-09-08)

  • Fixed Nidus Prime’s body appearing incomplete when applied to the Mastery Rank 30 Blessing Relay statue.
  • Fixed Nidus Prime missing half his body when he is in Railjack Turrets.
  • Fixed Nidus Tennogen Skins showing too many Prime body parts with Prime Details enabled.
  • Fixed a script error when casting Nidus’ Ravenous with Insatiable Augment equipped.

Update 30.7 (2021-09-08)

  • Introduced Nidus Prime.

Hotfix 29.5.4 (2020-11-25)

  • Fixed Nidus’ Virulence not benefiting from Volatile Maggot / Strain Maggots.

Update 29.5 (2020-11-19)

  • Larva: Enemies killed while held have a chance of generating a Mutation stack for Nidus.

Hotfix 29.0.8 (2020-09-10)

  • Fixed Nidus’ infestation not applying color properly. As reported here!

Update 28.3 (2020-08-12)

  • Warframe Blueprint and Component costs from Simaris have been reduced by 50%!

Hotfix 28.2.1 (2020-08-01)

  • Made some micro-optimizations to Nidus maggots.

Hotfix 27.5.4 (2020-05-20)

Update 27.4 (2020-05-01)

  • You can now sell your duplicate Nidus Blueprints for 2500 Credits from your Inventory.

Hotfix 27.1.2 (2020-02-18)

  • Fixed enemies becoming permanently stuck in Nidus’ Larva pod if the ability expires while you’re a great distance away.

Update 27.1 (2020-02-04)

  • Fixed a script error related to Nidus’ Undying Passive.

Update 25.7 (2019-08-29)

  • Updated the following Warframe Ability Descriptions to better explain the Ability. Below are the latest edits:
    • Nidus’ Parasitic Link: “Bind to a target with parasitic link. When cast on an ally, both the host and Nidus have their Ability Strength increased. Linked enemies take some of the damage inflicted on Nidus.”

Hotfix 25.3.3 (2019-07-16)

  • Fixed an issue with recasting Nidus's Ravenous on same location not refreshing the ability duration timer.

Hotfix 25.0.8 (2019-05-31)

  • Fixed Maggots from Nidus not using the proper emissive colors.

Update 25.0 (2019-05-22)

  • Cephalon Simaris now sells Blueprints given during quests in his Offerings! This allows you to purchase these items in the event that you’ve accidentally sold them.

Hotfix 24.7.3 (2019-04-22)

  • Fixed having no Shields in Archwing if Inaros or Nidus are equipped.

Update 24.7 (2019-04-10)

Update 24.6 (2019-04-04)

  • The following abilities require ground to activate, but can now be cast in the air and will do a melee-esque slam to the ground:
    • Nidus Virulence

Hotfix 23.0.6 (2018-06-27)

Hotfix 22.20.8 (2018-06-05)

  • For consistency, damage link abilities (Trinity, Nidus, Nekros) will no longer transmit self-damage, but you will still get the damage reduction. This is particularly relevant for the healer/support class of Trinity who had become the go-to DPS frame in addition to the intended support roles. The re-release of Mods like Aviator added to some clever but ultimately uncharacteristic roles for Trinity.

Hotfix 22.20.1 (2018-05-17)

  • Fixed casting Nidus’ Larva to pull AI from ships resulting in teleporting them back to the ship after the ability ends.

Update 22.20 (2018-05-17)

  • Fixed Nidus’ Parasitic Link damage increase stacking indefinitely if cast on Mirages Hall of Mirror clones.

Hotfix 22.16.4 (2018-03-20)

  • Fixed Nidus’ Mutation not working when in the Relay Arsenal.

Update 22.16 (2018-03-15)

  • Fixed Nidus’ Virulence and Larva sometimes appearing completely black when cast.

Hotfix 22.13.2 (2018-02-16)

  • Fixed Nidus’ Ravenous Infested carpet not dissipating for Clients after a Host migration occurs.

Update 22.11 (2018-01-31)

  • Fixed Nidus’ Passive making you permanently invincible in the Simulacrum after switching Warframes.

Update 22.10 (2018-01-25)

  • Augment: Larva - Mod TT 20px.png Larva Burst
  • Fixed an issue where enemies would be stuck on the ground instead of getting pulled into Nidus' Larva.

Hotfix 22.8.2 (2018-01-04)

  • Fixed Nidus’ Ravenous not working when Particle Quality is set to low.
  • Fixed Nidus’ head appearing detached in his diorama.

Hotfix 19.6.1 (2017-01-13)

  • Fixed recasting Nidus’ Ravenous not refreshing Duration.
  • Fixed Nidus losing a Mutation Stack after falling into a pit.
  • Fixed Nidus being able to use Parasitic Link on disabled Corpus Security Cameras and Turrets.

Update 19.6 (2017-01-11)

  • Increased the base health of Nidus’ Maggots to 1k.
  • Increased Nidus’ Mutation Stack consumption from 10 to 15 when knocked into a bleedout state/death. The task of regaining 10 Stacks is quickly obtainable, making this consequence for dying too light. Although 15 Stacks is not a huge jump, we’re hoping it’s closer to that sweet spot!
  • Entering a Nullifier bubble will now drain down Mutation Stacks the longer you are in the bubble.
  • To increase the visibility of Nidus' Maggots, holding down Nidus’ Virulence will now display a HUD marker on them. Keep in mind that casting Virulence on Maggots cause them to detonate!
  • Nidus’ Ravenous Maggots no longer auto detonate when feasting on enemies. Previously the Maggots could do a majority of the grunt work and you were able to watch the carnage and gain Stacks at the same time. Now to pop the Maggots you’ll need to cast Virulence on them and rejoice in your hard earned Stack accumulation. It’s also worth noting that with testing by our team, the Stack rhythm before and after this change wasn’t noticed at all.
  • Improved the FX of Maggot explosion to better represent the intended area of explosion.
  • Nidus’ Ravenous Maggots will still attack but no longer latch on other Infested Maggots or Kuva Jesters due to awkward animations.
  • Fixed FX, Maggots, & Health regeneration while in Ravenous staying around forever if cast by a Client who leaves.

Hotfix 19.5.7 (2017-01-06)

  • Fixed a script error from Parasitic Link ability.
  • Fixed Virulence cast sound being doubled for Clients.

Hotfix 19.5.5 (2017-01-03)

  • Fixed a crash that would sometimes occur by Nidus’ Maggots exploding when latched onto an enemy.

Hotfix 19.5.4 (2017-01-03)

  • Changed Nidus’ Parasitic Link and Ravenous ability stat description from ‘ADAPTATION STACKS COST’ to ‘MUTATION STACKS COST’.
  • Increased the brightness of both Nidus’ Ravenous Maggot tails and their death FX to improve visibility.
  • Improved Nidus’ Maggot visibility if performance was suffering.
  • Nidus’ Larva will now release an enemy if it fails to ragdoll them within 3 seconds. Before, enemies that were considered ragdoll immune (not including enemies trapped in Bastille) resulted in the inability to cast Larva again due to Larva staying perpetually latched to the enemy.
  • Nidus’ Larva no longer latches enemies trapped in Vauban’s Bastille.
  • Fixed a crash caused by Nidus’ Parasitic Link ability.
  • Fixed Nidus' alternate animation sets displaying placeholder text.
  • Fixed Nidus’ Larva getting destroyed by high damage Quanta alt fire.
  • Fixed being able to heal Defense Targets with Nidus’ Ravenous ability.

Hotfix 19.5.2 (2016-12-23)

  • Fixed Virulence going through enemies without hitting them.

Hotfix 19.5.1 (2016-12-22)

  • Fixed Nidus’ Parasitic Link being able to stun bosses.
  • Fixed disappearing Nidus Larva.
  • Fixed script error when clients try to cast Ravenous after their previous cast was nullified.
  • Fixed Nidus Larva not appearing for clients and slime FX on enemy not being removed.

Update 19.5 (2016-12-22)

  • Warframe introduced to the game.

Edit Tab

Ability SFX

  • Using any ability