Margulis, or Archimedean Margulis, was an elite scholar of the Orokin Era mentioned during The Second Dream, The Silver Grove, The War Within, Chains of Harrow and Apostasy Prologue. Although she is long dead by the time the quests take place, her actions were the catalyst to the birth of Tenno and ultimately led to the development of Warframes.
After destroying the Pendula that used to keep the Moon within the Void, a number of conversations between Margulis and several Orokin figures (most of whom, with the exception of an individual named Ballas, remain nameless) are heard, most likely a recollection of memories. In these conversations, Margulis argues to the rest of the Orokin regarding the orphaned children of the Zariman Ten Zero, as they have been under her care, despite the rest of the Orokin's wishes that they should be killed out of fear of their power. Margulis, as indicated by Lotus, contributed to a process known as 'Transference' in which a Tenno's consciousness and power could be channeled through a vessel strong enough to contain it, leading to the creation of the Warframe.
It is heavily hinted by the dialogue, and by the Lotus, that Margulis was executed for defending the Tenno, and disobeying some not entirely disclosed Orokin laws. The sentence was carried out by The Seven (the council of Orokin judges) to which Margulis states that the Orokin, for all their perfect appearances are "rotted through and through".
Margulis was mentioned to recruit researchers to help with Transference therapy, presumably to build surrogate bodies for the children of Zariman Ten-Zero. As Silvana, the researcher involved in the creation of The Silver Grove, puts it "she needed the best Infestation biologist". But later, it seemed the project was turned into the creation of Warframes and Margulis was removed from the project for her objection.
- The name Margulis is most likely a reference to Lynn Margulis, an American evolutionary theorist who was a key proponent for the significance of symbiosis in biological evolution.
- Margulis was briefly alluded to in Update 17.0 (2015-07-31) through a cryptic Orokin message that would occasionally appear at the start of a mission. In the said message, one of the lines mentions "Margulis implantation intact". The majority of the message suggests some relation to the Reservoir as well. A full translation of the message can be viewed below;