Well, you got a reaction. Big as a house and half as smart. Knock it on the head, eh?

Konzu, talking about Hemocyte

The Hemocyte is a gigantic Infested creature that can be encountered during Operation: Plague Star. It is summoned using an Infested Catalyst during the toxin mixing phase and drops the Hunter Set Mods.


  • When an Infested Catalyst is used on the Thrax Toxin during the toxin mixing phase, the final stage of the Plague Star Bounty will spawn a Hemocyte from the Infested boil. While the Hemocyte is alive, the Infested kill progress bar for that stage will be frozen regardless of how many Infested are killed, preventing players from accomplishing the objective.
  • Much like the larger and more ancient Lephantis, the Hemocyte has three different heads, each of which will have different attacks they can use against players.
    • The Corpus head is a square head with green lighting, which will launch a wide barrage of infested spores that release clouds of toxic gas on impact.
    • The Grineer head has a long, triangular jaw with blue lighting, wielding a massive scythe that it uses to slash at enemies in close range.
    • The Ancient Infested head has a long snout with orange lighting, and fires a swarm of homing projectiles that deal damage on impact.
  • The only common attack available to the Hemocyte is an area-of-effect radial slam that can knock down players, visible as a yellow shockwave emanating from it.
  • The Hemocyte's outer skin is invulnerable to all weapons. However, each head will open up to reveal a weakspot whenever they launch an attack, with said weakspots being vulnerable to weapons fire and immune to status effects. Like Lephantis, there is damage cap mechanic for every shot, meaning that shots that deal damage above a certain threshold will be significantly reduced by a percentage amount. Each head has its own health, and when killed the destroyed head is removed, along with any attacks it had. The Hemocyte is defeated when all 3 heads have been destroyed.
  • If multiple Infested Catalysts are mixed into the toxin mixing phase, multiple Hemocytes will also appear during the final stage, with the number of Hemocytes appearing depending on how many Catalysts are mixed in, e.g. if two Catalysts are mixed in, two Hemocytes will spawn in the final stage. As up to four Infested Catalysts can be mixed per toxin, up to four Hemocytes can appear in the final stage.
  • Only one Hemocyte at a time will appear in succession, and are timed to appear at different progress markers on the Infested Kill progress bar.
    • If only one Catalyst is used, the Hemocyte will appear at 99% progress.
    • If two Catalysts are used, the Hemocytes will appear at 50% and 99% progress.
    • If three Catalysts are used, the Hemocytes will appear at 30%, 60%, and 99% progress.
    • With four Catalysts, the Hemocytes will appear at 25%, 50%, 75%, and 99% progress.
  • Each successive Hemocyte appearance will have a level higher than the last making it tougher and deadlier. Starting level is 10–18, depending on number of Eidolon Phylaxis used, and 10 levels added per successive appearance up to a maximum of level 48. With 4 Catalysts and 4 Phylaxis, the Hemocytes spawn at level 54, 64, 74 and 84.
  • Some toxin clouds spawned can deal around 150 damage per tick and spawn under the player.


  • Stay off the boil. It does enough damage to kill over time and players who go into down status while on the boil may not be revived by squadmates for this reason.
    • The radius from the boil extends past the dome several meters so a player may also die standing next to the boil.
  • Archwings can be used to gain a height advantage over the Hemocyte, allowing players to avoid the majority of its attacks as well as prevent being swarmed by the Infested accompanying it. Players should be wary of the Hemocyte Infested head's attacks however, as they are capable of tracking airborne targets and knocking players off their Archwings.
    • TitaniaIcon272 Titania's Razorwing130xDark Razorwing is ideal for this, as Titania cannot be knocked out of Razorwing mode, and her plethora of crowd-control abilities can be used to keep the Infested at bay.
  • The Hemocyte can yield extra drops if caught in HydroidIcon272 Hydroid's TentacleSwarm130xDark Tentacle Swarm using Mod TT 20pxPilfering Swarm or affected by NekrosIcon272 Nekros' Desecrate130xDark Desecrate.
    • Desecrate may not always have time to trigger due to the Hemocyte's body disappearing very quickly.
  • Warframe abilities with slowdown effect, such as RhinoIcon272 Rhino's RhinoStomp130xDark Rhino StompNovaIcon272 Nova's MolecularPrime130xDark Molecular Prime, FrostIcon272 Frost's SnowGlobe130xDark Snow Globe or an Operator's Temporal Blast, can make attacking Hemocyte's weak points easier. By using the ability when the weak points are exposed, Hemocyte's movement will be greatly slowed down thus giving extended time for players to attack the weak points.
  • Using any melee weapon that's capable of dealing Impact b Impact damage with Mod TT 20pxShattering Impact can completely strip the Hemocyte's armor, even when it's on the invulnerable phase.
  • An OberonIcon272 Oberon with 169% Strength and Mod TT 20pxGrowing Power can strip 100% of the armor by using HallowedGround130xDark Hallowed Ground and Reckoning130xDark Reckoning.


  • The Hemocyte is essentially a recolored Stage 2 Lephantis, with different lighting colors and slightly modified attacks. It is otherwise identical to the Lephantis in terms of tactics and weaknesses.
  • In Biology, Hemocytes are cells that form part of the immune system of invertebrates. They are part of the phagocyte group, responsible for consuming invading hostile cells or consuming and removing old or dead cells.
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