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Command the Infestation to mutate and grow ever more destructive.

This is Nidus, the adaptive, the scourge.

Nidus is a deadly plague for which there is no cure. You must control the strange disease.

Release Date: December 22, 2016

Epitome of the endlessly evolving Infestation, Nidus bends the vile corruption to his will, mutates his genetic potency to adapt and assimilates his victims with an insatiable parasitic hunger. Nidus and his strain developed in Update 19.5.

Manufacturing Requirements
Time: 72 hrs
Rush: Platinum64 50
Market Price: Platinum64 225 Blueprint Price: N/A
Time: 12 hrs
Rush: Platinum64 25
Time: 12 hrs
Rush: Platinum64 25
Time: 12 hrs
Rush: Platinum64 25


Nidus' main blueprint is acquired from The Glast Gambit quest. NidusIcon272 Nidus' component blueprints are acquired from Rotation C of Infested Salvage (Oestrus, Eris).

Additional main blueprints can be bought from Cephalon Simaris for ReputationLargeBlack100,000.
Drop Chance Expected Nearly Guaranteed
Chassis Blueprint 14.29% 12 – 13 C Rotations 52 ± 15 C Rotations
Neuroptics Blueprint 14.29%
Systems Blueprint 14.29%

Expected refers to total number of runs a player can expect to receive at least one of each drop associated with the respective values.

Nearly Guaranteed refers to the total number of runs a player needs to obtain a 99%, 99.9%, and 99.99% probability to receive at least one of each drop associated with the respective values.

For more detailed definitions and information on how these number were obtained visit here.


  • Nidus has the unique passive ability to infect other players both in combat and in a Clan Dojo with the "Helminth Virus" acquired from the Infested Room onboard the Orbiter. Nidus is the only Warframe that can be used to open the Infested Room without having a fully matured cyst.



Nidus infecting another Warframe

  • The word nidus (Latin root: "nest") is defined as the site of origin for disease or bacteria, or a place where bacteria multiplies.
  • Nidus is the first Warframe to use Kuva as a Blueprint ingredient.
  • Nidus is the second Warframe after InarosIcon272 Inaros to have no base shields whatsoever.
  • Nidus is also the first Warframe to use another type of ability resource besides energy, in the form of Mutation stacks.
  • Nidus is the first and only Warframe to innately regenerate Health.
  • The screech of Nidus' fourth ability was done by Digital Extremes sound designer, Willem Schonken. [1]


  1. Devstream #102

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Adaptive MutationEdit

The Infestation dwelling within Nidus mutates rapidly when used against his foes, fueling his abilities and yielding various symbiotic benefits. Nidus possesses various passive mechanics highlighted in the tabs below:

Mutation Stacks are a resource unique to Nidus, indicated by the Mutation counter and gauge displayed in the lower-right on the HUD, above the ability icons.

  • Every enemy hit by Virulence130xDark Virulence will grant Nidus 1 Mutation Stack.
    • Abilities are not required to deal damage to enemies, only ability contact is needed to increase Mutation stacks.
    • Mutation stacks are stored until used by the player. Stacks will not disappear in the event of a host migration.
    • Up to a maximum of 3 stacks can be stored. Each stack causes the gauge to gradually appear more infested. Upon reaching 3 stacks, the counter is hidden and the gauge is overlapped by Virulence's ability icon colored in red and black.
    • ParasiticLink130xDark Parasitic Link and Ravenous130xDark Ravenous each cost 1 stack to activate instead of using energy.
  • Nidus' appearance changes as more stacks are collected:
    • With the base skin:
      • At 1 stack, tendrils will protrude from his neck and upper spine, while the carapace around his ribs will open.
      • At 2 stacks, the carapace around his thighs and arms will open to reveal more infested flesh and tendrils beneath.
      • At 3 stacks, certain sections of his currently-equipped helmet will open up, and many more tendrils will be exposed.
    • With the Nidus Phryke Skin:
      • At 1 stack, he gains protective armor on his thighs, and his shoulder pads are covered in a cage-like armor with a protruding spike on the top.
      • At 2 stacks, a large curved blade appears on each of the shoulder pad spikes and his forearms are lined with a curved blade that extends two large spikes.
      • At 3 stacks, his face becomes covered with a crown-like visor.
    • When stacks fall below the required triggers, Nidus' appearance will revert to the appropriate stage.

If Nidus suffers fatal damage with at least 1 Mutation stack, it will be consumed, restoring 50% of Nidus' health.

  • A UI banner displaying "Undying" will appear at the top-center of the screen while this passive is activated. The required amount of Mutation stacks will be visibly subtracted from the counter and gauge.

Nidus' health regenerates at a rate of 5 health per second.

Abilities Edit

Virulence VirulenceIcon
Rupture the ground with a damaging fungal growth that steals energy from each enemy it strikes. For every five enemies hit, the Infestation mutates, multiplying its destructive force.
Strength:40 (damage)
Range:14 m
Misc:4 m (fungal growth width)
25 (energy refund per hit)

  • Nidus ruptures the ground to unleash a linear growth of fungal infestation 14 meters long and 4 meters wide toward the targeted location. Enemies struck by fungal growth are staggered, dealt 40 Puncture b Puncture damage amplified by the number of Mutation stacks accumulated, as well as refunding energy to Nidus for each enemy hit.
    • Enemies hit by Virulence contribute to Nidus' Mutation gauge.
    • Virulence's total damage uses the following expression when accounting for Mutation stacks:
      Amplified Damage = Base Damage × (1 + Number of Stacks)
      • With 3 stacks, a rank-3 Virulence's total damage will be increased to:
        40 × (1 + 3) = 160 damage (decimals are rounded down to the nearest whole number during calculations).
  • Maggots from Ravenous130xDark Ravenous can be manually detonated when impaled by Virulence's fungal growth, exploding for damage and contributing to the Mutation gauge per enemy hit.
  • Holding the ability key displays a rectangular range indicator on the horizontal plane in front of Nidus. Releasing the key casts Virulence. Range indicator color is affected by the chosen energy color.
    • Player can move the aiming reticle while holding down the button to aim Virulence at the desired direction.
    • While held, the player can still perform other actions such as moving, jumping, firing weapons, and casting other abilities. Releasing the key while in midair will exit range indicator mode without casting Virulence.
    • While held, Maggots from Ravenous will be marked on the HUD, allowing increased visibility for selective detonation using Virulence.
  • Virulence will cast toward the targeted location regardless of Nidus' orientation.
  • Cannot be cast while in mid-air.
  • Cannot be recast until the fungal growth's maximum length is reached or until it cannot spawn any further due to obstruction.
  • Virulence does not spawn up or down high terrain elevations, but does flow up and down stairs and ramps.
  • Can stagger enemies to help keep them in place for recasts.
  • Can allow Nidus to earn extra energy when it hits at least 2 enemies.
  • Collect Mutation stacks to amplify Virulence's damage drastically over the course of a mission.
  • Hold the ability key to line up Virulence on groups of enemies before releasing to cast. This is an efficient method to gather extra energy and collect hits for stacks. Jump and release the ability key to toggle off the range indicator without casting the ability.
  • Can detonate Maggots spawned from Ravenous by you and any Nidus players in your squad. Hits from both the fungal growth and maggot explosion each count toward the Mutation gauge. Blow up anyone's Maggots to help you and your brethren gather more stacks quickly!
  • If the fungal growth cannot spawn any further because of obstruction, you can immediately recast Virulence.

Larva LarvaIcon
Spawn an Infested pod that erupts with tendrils, latches onto nearby enemies and pulls them in.
Duration:4 s
Range:8 m

  • Nidus ejects an infested larva toward the targeted location over unrestricted range. Upon impact, the larva rapidly matures into a floating mass of infested tentacles that sprouts tendrils to grab all enemies within a radius of 8 meters, Impaired b Impairing them. Larva will wither away when it has no enemies to grip, is cast when no enemies are in range, or after 4 seconds have elapsed.
    • Larva will only grab enemies when it spawns.
    • Grabbed enemies can still take damage from normal sources.
  • Larva is a One-Handed Action and can be cast while in midair.
  • Cannot be recast while active.
  • Use Larva to Impaired b Impair enemies, making hitting them with Virulence130xDark Virulence and gaining Mutation Stacks easier.

ParasiticLink ParasiticLinkIcon
Parasitic Link
Bind to a target with a parasitic link. For allies, both the host and Nidus deal increased damage. Linked enemies take the damage inflicted on Nidus.

Mutation Stacks Cost: 1

Strength:20% (damage bonus)
50% (damage redirection)
Duration:20 s
Range:20 m

  • Nidus expends a single Mutation Stack to perform symbiosis with a targeted ally or enemy Warframe within 20 meters. The link persists as long as Nidus and his target remain in range of each other, lasting for 20 seconds or when manually deactivated by pressing the ability key again.
    • Parasitic Link does not require line-of-sight to maintain connection between Nidus and his target.
    • If the target dies during cast before the link is attached, the single Mutation stack used for Parasitic Link will be refunded.
  • When linked with an ally Warframe, Nidus and his target both receive a 20% damage bonus. When linked with an enemy, Nidus transfers 50% damage received to the target instead.
  • Parasitic Link is a One-Handed Action and can be cast while in midair.
  • Nidus and the target are visibly covered in infestation and connected via a tether of biochemical energy, which is affected by the chosen Warframe energy color.
  • Cannot link to a target already affected by Parasitic Link. Multiple Nidus players cannot link to the same target, nor to each other while their own Parasitic Link ability is active.
  • When connected to another Nidus player, both players will use the damage bonus from the casting player; the link will break if the partner activates Parasitic Link on a different target.

Ravenous RavenousIcon
Gluttonous maggots swarm nearby enemies, feasting until they are hit with Virulence burst with Infestation. The maggots benefit from Mutation and each enemy hit adds to the Mutation stack.

Mutation Stacks Cost: 1

Strength:200 (explosion damage)
10 (health regen per second)
Duration:10 s
Range:4 m (explosion radius)
Misc:8 m (ability diameter)
9 (number of maggots)
100 (maggot health)
10 (maggot toxin damage)

  • Nidus converts one Mutation stacks into ravenous Infestation, which spreads outward from Nidus and across the surrounding landscape to create spawning grounds with a diameter of 8 meters, lingering for 10 seconds. Nidus and his allies will regenerate 10 health per second when inside the spawning grounds.
    • Health regen buff area is an invisible cylinder, allowing eligible targets to retain the buff up to a height of 8 meters above the spawning grounds.
    • Ravenous' health regeneration is visible to players as a buff icon beside the shield and health indicators on the HUD, indicating the health regen rate.
    • Health regeneration affects ally Warframes and ability-summoned units.
  • Infested cysts form on the spawning grounds, hatching up to 9 Maggots that seek out nearby enemies to feast upon. Once enemies are detected, Maggots frenzy with increased movement speed and leap toward their prey to latch onto them. While attached to an enemy, each Maggot will continuously stun its target and inflict 10 Toxin b Toxin damage per second until the target dies or Maggot expires.
    • The Toxin b Toxin damage is amplified by the number of Mutation stacks accumulated using the following formula: Toxin Damage × (1 + Number of Stacks)
  • When detonated by Virulence130xDark Virulence, when their hosts die, when killed, or when Ravenous duration expires, Maggots explode to deal 200 Blast b Blast damage to all enemies within a 4 meter radius.
    • Explosion damage is affected by the number of Mutation stacks accumulated.
  • Maggot explosion and Toxin b Toxin damage are calculated and predetermined when Ravenous is cast. All three will not be recalculated if any changes in Mutation stacks occur while Ravenous is active.
  • Has a casting time of 1.5 seconds.
  • Ravenous can be recast while active.
    • Only one instance can be active at a time.
    • Recasting Ravenous while on the spawning grounds will refresh its duration without relocating it.
      • Maggot explosion and Toxin b Toxin damage will not be recalculated if an instance of Ravenous is recast.
      • Due to Ravenous' casting time, players will have to recast at least 1.5 seconds before the duration ends to maintain the old instance.
    • Recasting Ravenous away from an active spawning ground creates a new instance at the new location while removing the older instance.
      • Maggot explosion and Toxin b Toxin damage are recalculated if a new instance of Ravenous is created.
  • Maggots and spawning grounds possess unique properties as independent entities from Nidus:

  • Maggots possess a base health of 100 and draw enemy aggro.
    • Maggot health is not affected by the number of Mutation stacks accumulated.
  • Maggots have their own rank.
    • Maggot rank is identical to Nidus' rank (e.g., a rank-25 Nidus' Maggots will be level 25).
    • Currently it's not known what effect the maggots' rank has.
  • Maggots can not be damaged by Nidus or allies.
  • When Maggots cannot attach to enemies, they will instead bite or seek other enemies to latch on to.
  • Maggot lifespan is tied to the duration of the ability, during which they will actively seek out enemies or wander around or away from the spawning grounds.
  • Maggots will automatically explode when killed, when Ravenous' duration expires, when their hosts die, or when detonated by Virulence.
  • On death, Maggots respawn from cysts throughout the duration of Ravenous, up to the maximum number of 9 active Maggots.
  • Nidus maggots are affected by his chosen Warframe energy color.
  • After casting Ravenous, there will be a 4 second delay before the Maggots start running towards/attacking nearby enemies.
  • Opponents can just bullet jump away as maggots can’t attack air.

  • Spawning grounds is created at the location where Nidus casts the ability.
  • Spawning grounds' infestation does not expand up or down high terrain elevations, but does flow up and down stairs and ramps.
  • Within the spawning grounds, various unique models will spawn for visual representation only. Players and AI can path through them unhindered.
    • Textures on the ground are blended with an infestation mesh.
    • Three infested nests erupt on the edges of the infestation, positioned in triangular vertices. Nests glow, pulsate, and emit spore particles, which are affected by the chosen energy color.
    • Numerous patches of infested flora resembling tall grass encompass the ground, rustling when brushed past by players and AI while glowing in the chosen energy color.
    • Several infested branches sprout from the infestation to attach to nearby walls and objects in vertical and diagonal axis. Branches glow in the chosen energy color.

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Hotfix 19.5.4
  • Increased Nidus’ Virulence width to 3m in Conclave. This also improves the ability to better hit enemies moving through it.

Hotfix 19.5.2

  • Increased the heal rate of Nidus’ passive.

Update 19.5

  • Introduced.
Last updated:Hotfix 23.1.3

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