Firing in short bursts and landing headshots will significantly increase its efficiency.
Reload time can be shortened by using a melee attack or dodge roll when the reload timer reaches about 3/4. This works because, like many older weapons, the magazine is updated at this time instead of at the end, making the remaining time extraneous.
Due to the weapon's high rate-of-fire combined with its low base damage, the Soma Prime can be ammo inefficient. Using Rifle Ammo Mutation and/or Rifle Scavenger can be used to recover a steady supply of ammo. Alternatively, ammo can be instantly replenished using Team Ammo Restores.
The Soma Prime's high ammo consumption makes Critical Delay a good option for it, as the mod enhances critical chance while slowing down rate of fire, improving its ammo efficiency.
Unlike other Prime weapons, weapon skins used on the Soma Prime will not change the weapon model to the non-Prime variant. The gold ring around the receiver will still appear with a skin applied, and the magazine will move behind the trigger.
The ring-like formation through which the Warframe holds the weapon with their left hand rotates while firing, making this one of the few primary weapons that have firing animations.
Like its non-prime version, the Soma Prime's magazine passes up through its receiver as it fires, with the portion of the magazine consumed indicating the amount of ammo left.