Bloxavarice wrote:

Oh, you can shoot through walls, too.

Primary:

Penta absolutely outdamages every other AoE weapon and oneshots nearly everything lower than lvl 40. Pretty sure the Tonkor beats out the Penta and is easily capable of putting down level 80+ enemies in a single well-placed shot. The only issue is that OP would have to wait until MR6(?) in order to build it~

Even potatoed the synapse requires at least 4 formas and nearly only rare mods to shine, but kills even high level single targets in the blink of an eye.

vs Grineer:

Fully modded, a Sybaris deals amazing amounts of damage, allowing you to take out elite units fast. Latron Prime is similar, but with less damage, a bigger clip size, better RoF and better ammo efficiency. Boltor Prime is extremely strong, but useless at greater distances. All of those weapons are pretty niche at best, but the Boltor Prime does have a pretty nice DPS I admit. 

vs Corpus

Karak can be modded to be extremely effiecient vs Corpus. Penta. Explosive Dmg + Corpus = fun. If you like shotgun gameplay the boar prime can be interesting since its absolutely devasting in melee combat The Karak is mastery rank fodder...

vs Infested

Ignis for low level Infested. Remember that ancients are vulnerable to pierce damage and the higher the level, the more ancients spawn. Take a anti-grineer weapon or do melee I had more fun with the Attica equipped with Thunderbolt for something like this, but the Ignis is more suited to >>low-level<< Infested

Secondary:

Marelok is pure destruction and the best secondary ingame. Kunais, Despair, Hikous are great alternatives but require heavy modding to shine. Marelok/Vaykor Marelok are pretty decent sidearms, sure, but the Twin Grakata and Aksomati do a pretty wonderful job at annihilating entire hallways with little issue.

Melee

Dakra Prime with Scarlet Derwish is the best melee weapon ingame. No doubt. Orthos Prime is fine aswell, way less damage but more range. Fang prime are nasty aswell and shred armored targets within seconds, but you need to be VERY close. 

Nikana and its upgrade are awesome against Infested since they only deal slash damage and have a big range especially with stance mods Scarlet Dervish? I can only assume you mean "Crimson Dervish", in which case, yes, the Dakra Prime is a pretty fine weapon. However, saying it's the BEST is definitely pushing it. I dare say that honor would go to the Redeemer, with a character that has the ability to go into stealth. Being able to push out 120k+ true damage [ignores armor, etc] to an entire line of level 100+ enemies per shot is pretty hard to pass up~

No-Nos

Any kind of bow or sniper. Its just plain stupid especially in survival or defense mission where you have to kill masses of enemies. In these mission you'll prop deal less than 1% of total damage when your warframe has no offensive powers. Unless you know how to take out multiple enemies with a single shot, dont! This statement I can agree with; In missions such as Survival, Excavation, or Defense, a sniper rifle or bow is a pretty bad choice, unless you have a group that can pull enemies into a sufficiently large cuddlepuddle so a single shot can annihilate them or, at the very least, protect the objective/hold the line so you can pick off the more troublesome targets.

Slow melee weapons (mostly the 2handed) dont really help your cause and will mostly make you static, allowing enemies to hit you easier, both melee and ranged. I kind of agree with this statement; heavy weapons usually build momentum, which means you can tank hits without worrying about stagger. Of course, this is only beneficial if you're playing a frame that is meant to soak up hits or, just as optimal, go with a frame that has invisibility as an option.

Any throwing weapons. Just wtf. Spira/Spira Prime say 'sup.

Any kind of whip. To hard to handle and especially useless in melee situations(!) Atterax as a melee weapon on an Excalibur is actually a pretty fantastic idea. Its high critical multiplier, combined with a high critical chance can make Exalted Blade do some pretty ludicrous damage. I dare say that the Dual Cleavers with a crit damage/chance modifier and the syndicate mod for it are a better alternative, however.

inb4 replies including:

'MUH PARIS PRIME' I tend to get better results out of the Dread bow, but it does do a decent job of killing off armored Grineer, especially if you go corrosive damage on it.

'MUH OGRIS' Also pretty lame

'MUH TWIN GREMLINS' ??? Not sure if you mistakenly wrote "Twin Gremlins" instead of "Twin Grakata", but the Twin Gremlins are pretty lame.

'MUH PHAGE' Haven't used it, so I cannot attest to its damage